Synthesis of Tetraphenylmethane Derivatives, Dibenzylglycines and Allylated Aromatics via the Suzuki-Miyaura Coupling Reaction

The thesis deals with the application of the Suzuki-Miyaura (SM) cross-coupling reaction to various molecular entities. A brief introduction to the Suzuki-Miyaura cross-coupling reaction with emphasis on its application to unusual amino acids, peptides and polycyclic compounds is included in Chapter 1. Tetraphenylmethane (TPM) belongs to a unique class of compound where all the four substituents are linked to a single sp3-hybridised carbon atom. With growing importance of TPMs for the construction of novel functional nanometer-sized entities; there is a need to develop a general methodology for the preparation of new TPMs. In this respect, a general methodology for the synthesis of various TPM derivatives is reported using the SM cross-coupling reaction as a key step in Chapter 2. Conceptually new and a general synthetic methodology for the preparation of highly functionalized dibenzylglycine (Dbzg) derivatives via the SM cross-coupling reaction is described in Chapter 3. More Info

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