Surfactant Therapy for Adult Respiratory Distress Syndrome

Adult Respiratory Distress Syndrome (ARDS) is characterized by high permeability pulmonary edema and intrapulmonary shunting caused by endothelial cell damage, which results in refractory hypoxemia. Blood and its components flood the alveoli and may be responsible for the inhibition of lung surfactant (LS) in trauma based ARDS. In the present study, various blood components/derivatives (whole blood, membranes obtained from whole blood cells, lysed blood, homogenized blood clot, serum, platelet rich plasma, platelet poor plasma and individual plasma proteins: albumin etc.) were compared for their inhibitory role on surface activity of dipalmitoyl phosphatidylcholine (DPPC) monolayers, the main component of lung surfactant. After identification of the main inhibitory hematological agent, the susceptibility of different phospholipids mixtures to the inhibitory agents was evaluated. Experiments were performed using a Langmuir-Blodgett trough at physiological temperature (37 ÚC), pH 7.0 and using 0.9% saline as the sub-phase. More Info

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